Atista Indica, Glycosmis pentaphylla    
Synonyms: Glycosmis arborea, Glycosmis quinquefolia
Gin Berry, opal orange, orangeberry, rum berry, tooth brush plant • Bengali: আশশেওড়া, বন জামির, মাতখিলা।
Family: Rutaceae (Lemon family)

Pharmacological activities

Various in vitro and in vivo studies on extracts and individual phytoconstituents isolated from G. pentaphylla have demonstrated prominent anticancer, antimutagenic, antimicrobial, anthelmintic and mosquitocidal activities owing to selective and non-selective cytotoxic effects on vital biological targets. Extract and individual compounds have also showed antidiabetic, antihyperlipidemic, anti-oxidant, anti-inflammatory, analgesic, antipyretic, wound healing and anti-arsenicosis properties.

Ethnopharmacological relevance

Glycosmis pentaphylla (Retz.) DC. is a perennial shrub indigenous to the tropical and subtropical regions of India, China, Sri Lanka, Myanmar, Bangladesh, Indonesia, Malaysia, Thailand, Vietnam, Philippine, Java, Sumatra, Borneo and Australia. The plant is used extensively within these regions as a traditional medicine for the treatment of a variety of ailments including cough, fever, chest pain, anemia, jaundice, liver disorders, inflammation, bronchitis, rheumatism, urinary tract infections, pain, bone fractures, toothache, gonorrhea, diabetes, cancer and other chronic diseases.


The plant is often used in traditional medicine, both on its own and as an ingredient of various medicinal mixtures. Several alkaloids and amides that have been isolated from the plant are reported to have biological activities Glycozolidol, a carbazole alkaloid isolated from the roots, is active against some gram-positive and gram-negative bacteria. Leaf and stem bark extracts have been shown to have a healing effect upon damaged liver tissue. Extracts of the root bark have been shown to exhibit significant activity in the treatment of diarrhoea. An ethanol extract was found to be more effective at lower dosages than an aqueous extract. A steam distillate of the leaves has shown high antifungal activity against Cladosporium cladosporioides, but no activity against Staphylococcus aureus or Escherichia coli. A decoction of the roots is taken to treat bilious attacks. A decoction of roots and leaves is taken for intestinal trouble. An infusion of leaves and roots is given after childbirth as a protective medicine. The leaves are considered appetitive, stomachic and an infusion of roasted leaves is prescribed for women after delivery as an appetizer. In traditional Indian medicine, the plant is used to treat diarrhoea, coughs, rheumatism, anaemia, and jaundice. Juice of the leaves is used in fever, liver complaints and as a vermifuge. A paste of the leaves, mixed with ginger, is applied for eczema and skin affections. A decoction of the roots is given for facial inflammation.

Other Uses

Alkaloid extracts of the roots have been shown to inhibit crown gall tumours produced by Agrobacterium tumefaciens in a potato disk bioassay. The roots have also been shown to inhibit the growth and survival of larvae of the citrus root weevil, Diaprepes abbreviatus, when incorporated in their diet. A petroleum ether extract of the root has been shown to be lethal to the larvae of Culex quinquefasciatus, Culex sitiens, Aedes aegypti and Anopheles stephensi. Leaf extracts have shown a high degree of nematicidal action against the adults and larvae of the nematode Radopholus similis; as well as larvicidal activity against the mosquito Culex quinquefasciatus. The bio-active compound responsible for this activity was identified as the quinazolone alkaloid arborine. The pale wood is sometimes used for tool handles.


Causes & Symptoms for Atista Indica
A remedy for worms, colic pain, biliary and gastric problems.
It helps in regulating the liver functions.
It is used in indigenous medicine for cough, jaundice, inflammation.
Atista Indica is a great remedy for unquenchable thirst during hot stage.
Mind and Head

Weak memory; indifferent mood indicates Atista Indica.

Pain in one temple at a time with vertigo in the morning.

Eyes, ear, nose

Useful in trembling of light before eyes, after sleep.

For humming sound in the ear it gives a relief

Atista Indica is used in epistaxis (nosebleed), dried cold and catarrh.

Mouth and Throat

Bleeding gums; dull pains at the root of the teeth.

Inflammation of the tonsils after the increased or rise of body temperature.

Stomach and abdomen

Constant spitting in the morning with occasional belching of salty water;flatulence temporarily relieved by eructations.

Frequent eructation after a meal; heart-burnt 3-4 hours after food is relieved with Atista Indica.

Colicky pain round the naval, drawing pain in the renal region.

Stool and Anus

Pale earthly stool; bloody mucous stool with or without force indicates this remedy.

Urinary complaints

It relieves the electric-like throbbing pains in urethra.

Male complaints

Early semen discharging at night due to over excitement.


Atista Indica relieves the heaviness and numbness in the legs.


  1. Krishan Lal;flowersofindia;Gin Berry.
  2. Useful Tropical Plants;Ken Fern; Glycosmis pentaphylla
  3. Labony Khandokar, Md. Sazzadul Bari, Veronique Seidel, Md. Areeful Haque; Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicologucal profike of Glycosmis pentaphylla; Journal of Ethnopharmacology; sciencedirect; Volume 278, 5 October 2021, 114313
  4. bhphomoeopathy; Atista Indica
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